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IJEB Vol.46(06) [June 2008] >


Title: Effect of Withania somnifera Dunal in ethanol-induced anxiolysis and withdrawal anxiety in rats
Authors: Gupta, Girdhari Lal
Rana, Avtar Chand
Keywords: Elevated plus maze
Ethanol
Withania somnifera
Withdrawal anxiety
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Withania somnifera (WS) or its psychotropic preparation is known to play a critical role in morphine, alcohol and benzodiazepines addiction. This study investigates the role of WS in acute ethanol and withdrawal from chronic ethanol consumption using elevated plus maze paradigm in rats. Acute administration of ethanol (1.5-2 g/kg, ip) triggered anxiolytic effect and withdrawal from prolonged ethanol (9% v/v ethanol, 15 days) consumption elicited enhanced behavioral despair (anxiety). Acute administration of WS (50 mg/kg, oral) potentiated the anxiolytic action of subeffective dose of ethanol (0.5 or 1 g/kg, ip). Moreover, the ethanol withdrawal anxiety was markedly antagonized in dose dependent manner by WS at 200 and 500 mg/kg or higher dose of ethanol (2.5 g/kg). However, co-administration of subeffective doses of WS (50 mg/kg, oral) and ethanol also attenuated withdrawal-induced anxiety due to chronic ethanol (9% v/v ethanol, 15 days) consumption. The results suggest the protective effect of WS in the management of ethanol withdrawal reactions.
Page(s): 470-475
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(06) [June 2008]

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