NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(06) [June 2008] >

Title: Mechanism of vasorelaxant activity of a fraction of root extract of Sesamum indicum Linn.
Authors: Kumar, P Suresh
Patel, J S
Saraf, M N
Keywords: Aorta
Sesamum indicum
Issue Date: Jun-2008
Publisher: CSIR
Abstract: The petroleum ether soluble fraction (SIPE) of the root extract of S. indicum was evaluated for the vasorelaxant activity using isolated rat aorta. SIPE up to 180 µg/ml concentration significantly inhibited phenylephrine- and KCl-induced contraction to the extent of 98.13 ± 6.37 and 70.19 ± 3.43% respectively in isolated rat aorta in a concentration dependent manner. The vasorelaxant activity was not blocked by propranolol (10 µM), atropine (1 µM) indomethacin (10 µM) and glibenclamide (10 µM). Influence of SIPE on phenylephrine-induced contractions in aortic preparations in absence of functional endothelium and on pre-incubating the tissue with L-NAME (300 µM) or methylene blue (10 µM) was also studied. SIPE at 180 µg/ml concentration could elicit partial relaxation in presence of L-NAME or methylene blue to the extent of 34.26 ± 6.13 and 25.66 ± 10.95% respectively. However, in absence of functional endothelium, SIPE exhibited little relaxation to the extent of 6.70 ± 4.87%. These studies revealed that the vasorelaxant activity of SIPE was chiefly mediated through endothelium-dependent pathway.
Page(s): 457-464
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(06) [June 2008]

Files in This Item:

File Description SizeFormat
IJEB 46(6) 457-464.pdf213.47 kBAdobe PDFView/Open
 Current Page Visits: 691 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 166895 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: