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Title: Mechanism of vasorelaxant activity of a fraction of root extract of Sesamum indicum Linn.
Authors: Kumar, P Suresh
Patel, J S
Saraf, M N
Keywords: Aorta
Sesamum indicum
Issue Date: Jun-2008
Publisher: CSIR
Abstract: The petroleum ether soluble fraction (SIPE) of the root extract of S. indicum was evaluated for the vasorelaxant activity using isolated rat aorta. SIPE up to 180 µg/ml concentration significantly inhibited phenylephrine- and KCl-induced contraction to the extent of 98.13 ± 6.37 and 70.19 ± 3.43% respectively in isolated rat aorta in a concentration dependent manner. The vasorelaxant activity was not blocked by propranolol (10 µM), atropine (1 µM) indomethacin (10 µM) and glibenclamide (10 µM). Influence of SIPE on phenylephrine-induced contractions in aortic preparations in absence of functional endothelium and on pre-incubating the tissue with L-NAME (300 µM) or methylene blue (10 µM) was also studied. SIPE at 180 µg/ml concentration could elicit partial relaxation in presence of L-NAME or methylene blue to the extent of 34.26 ± 6.13 and 25.66 ± 10.95% respectively. However, in absence of functional endothelium, SIPE exhibited little relaxation to the extent of 6.70 ± 4.87%. These studies revealed that the vasorelaxant activity of SIPE was chiefly mediated through endothelium-dependent pathway.
Description: 457-464
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.46(06) [June 2008]

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