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Title: Moderate physical training increases brain insulin concentrations in experimental diabetic rats
Authors: Leme, Jose Alexandre Curiacos de Almeida
Gomes, Ricardo Jose
Mello, Maria Alice Rostom de
Luciano, Eliete
Keywords: Brain;Diabetes;Insulin;Physical training;Rat
Issue Date: Jun-2008
Publisher: CSIR
Abstract: Insulin is an important modulator of growth and metabolic function in the central nervous system. The aim of this study was to investigate the influence of swimming physical training (at 32°±1oC, 1 hr/day, 5 days/week, with an overload equivalent to 5% of the body weight, for 4 weeks) on brain insulin concentrations in alloxan induced type 1 diabetic rats. Training attenuated hyperglycemia but had no effect on insulinemia in diabetic rats. Hematocrit and blood albumin values remained without changes. Brain insulin did not change in diabetic rats. However, physical training increased the concentration in both control and diabetic rats. It is concluded that in the present experimental conditions, diabetes had no influence on brain insulin, however moderate physical training increased the hormone in both control and diabetic animals.
Page(s): 443-446
ISSN: 0975-1009(Online); 0019-5189(Print)
Appears in Collections:IJEB Vol.46(06) [June 2008]

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