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Title: Synthesis and cytotoxic evaluation of undecenoic acid-based oxime esters
Authors: Vijayendar, Venepally
Kaki, Shiva Shanker
Krishna, E Vamshi
Misra, Sunil
Prasad, R B N
Jala, Ram Chandra Reddy
Keywords: Oxime esters;Undecenoic acid;Benzaldehydes;Cytotoxicity
Issue Date: Aug-2018
Publisher: NISCAIR-CSIR, India
Abstract: A series of undecenoic acid-based aldoxime esters have been synthesized using various substituted benzaldehydes and undecenoic acid. These oxime esters have been evaluated for their cytotoxic activities against HeLa, B16-F10, SKOV3, MCF7 and CHO-K1 normal cell line using MTT assay. Most of the synthesized compounds exhibit cytotoxicity. Particularly, 2,3-dimethoxy (IC50 value 12.48µM) and 3-methoxy (IC50 value 13.58µM) derivatives exhibit promising activities against SKOV3 cell lines. All the synthesized compounds are non-toxic towards the Chinese hamster ovary (CHO-K1) normal cell line.
Page(s): 1015-1022
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(08) [August 2018]

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