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Title: Synthesis and biological evaluation of 2-azetidinone and thiazolidine-4-one derivatives containing dibenzothiazepine nucleus
Authors: Tailor, Jitesh H
Zadafiya, Shilesh K
Malik, Gulammustafa
Rajani, Dhanji
Keywords: Dibenzo[b,f][1,4]thiazepine hydrazone;Chloro acetylchloride;Thioglycolic acid;Antimycobacterial activity;Antimicrobial activity
Issue Date: Aug-2018
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, 3-chloro-1-(dibenzo[b,f][1,4]thiazepin-11-ylamino)-4-(substituted phenyl)azetidin-2-one 2a–k and 3-(dibenzo[b,f][1,4]thiazepin-11-ylamino)-2-(substituted phenyl)thiazolidin-4-one 3a–k derivatives have been synthesized via the reaction of (Z)-11-(2-(substituted benzylidene) hydrazinyl) dibenzo[b,f][1,4] thiazepine 1a-k with chloro acetyl chloride and thiogycolic acid respectively under mild reaction conditions. The structures of all synthesised compounds have been assigned on the basis of FT-IR, 1H and 13C NMR spectral data as well as elemental analysis. The title compounds have been screened for their preliminary in vitro antimicrobial activity against a panel of pathogenic strains and in vitro antimycobacterial activity against Mycobacterium tuberculosis H37 Rv.
Page(s): 1051-1059
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(08) [August 2018]

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