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Title: Spiro-heterocycles containing 1,3,4-oxadiazole: A convenient synthesis of 3-(5-substituted phenyl-1,3,4-oxadiazole-2-yl)-5,8-dithiaspiro[3,4]-octan-2-ones and 1,4-dithia-6-azaspiro[4,4]-nonan-7-ones
Authors: Tiwari, Shailendra
Singh, Kamal Pratap
Pathak, Poonam
Ahmad, Akeel
Keywords: Substituted phenyl-1,3,4-oxadiazole;Dithiaspiro;Azaspiro;Antimicrobial;Antibacterial activity;Antifungal activity
Issue Date: Aug-2018
Publisher: NISCAIR-CSIR, India
Abstract: A new series of novel 3-(5-substituted phenyl-1,3,4-oxadiazole-2-yl)-5,8-dithiaspiro [3,4]-octan-2-ones and 1,4-dithia-6-azaspiro[4,4]nonan-7-ones have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strain of bacteria and fungi. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) have been determined for the test compounds as well as for reference standards. Compounds 4a, 4c, 4d have shown good antibacterial activity whereas compounds 4b, 5a, 5c, 5d have displayed better antifungal activity.
Page(s): 1060-1064
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(08) [August 2018]

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