Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/44866
Title: Synthesis and antibacterial activity of 1,3-dione derivatives of 1-cyclopropyl-7- [4-(2,6-dimethyl/ dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid
Authors: Yadav, Pradeep
Hada, Sonal
Yadav, Dinesh Kumar
Kumari, Neetu
Keywords: Dimethylpyrimidine;Dimethoxypyrimidine;1,3-dione derivatives;Ciprofloxacin;Antibacterial activity
Issue Date: Aug-2018
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, a series of 1-cyclopropyl-7-[4-(2,6-dimethylpyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid, 1-cyclopropyl-7-[4-(2,6-dimethoxypyrimidin-2-yl-diazenyl)-piperzin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinolone-3-carboxylic acid and their dione derivatives have been synthesized in moderate yield. The newly synthesized compounds 5a-j have been characterized by IR, 1H NMR and elemental analysis. These compounds have been evaluated for their in vitro antibacterial activity against some gram-positive and gram-negative bacteria using conventional agar-dilution method. The antibacterial data of the newly synthesized compounds indicate that some of them showed better antibacterial activity as compared to their reference drug ciprofloxacin.
Page(s): 1065-1069
URI: http://nopr.niscair.res.in/handle/123456789/44866
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(08) [August 2018]

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