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Title: Synthesis and biological evaluation of some new furoxan derivatives as anti-inflammatory agents
Authors: Amir, Mohd
Verma, Jeevan S
Tariq, Sana
Somakala, K
Ehtaishamul Haq, S
Keywords: Furoxan;Nitric oxide donor;Anti-inflammatory;Ulcerogenicity
Issue Date: Jul-2018
Publisher: NISCAIR-CSIR, India
Abstract: A new series of furoxan derivatives (3a-k) have been synthesized and characterized by their IR, 1H NMR and mass spectral data. All the compounds have been screened for their anti-inflammatory activity. The compounds 3a, 3b, 3f, 3g, and 3i which show significant anti-inflammatory activity have been further studied for their ulcerogenic activities and nitric oxide releasing properties. Furoxan derivative 3-methyl-4-[{2-(2-phenylacetyl)hydrazono}methyl]-furoxan 3f showed greater anti-inflammatory activity comparable to standard drug ibuprofen. The compound also showed reduced ulcerogenicity and high nitric oxide releasing properties.
Page(s): 955-959
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(07) [July 2018]

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