Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/44748
Title: Synthesis and biological evaluation of some novel quinoline based pyrimidine derivatives
Authors: Desai, N C
Kotadiya, G M
Vaja, D V
Keywords: Quinoline clubbed pyrimidines;Antibacterial activity;Antifungal activity;Cytotoxicity;MIC
Issue Date: Jul-2018
Publisher: NISCAIR-CSIR, India
Abstract: A rational approach has been adopted for the synthesis of novel series of 3-((6-(2-chloro-6-methoxyquinolin-3-yl)-4-aryl-1,6-dihydropyrimidin-2-yl)thio)propanenitriles 5a-o. The synthesized compounds have been evaluated for their in vitro antimicrobial activity. Compounds 5j-m display broad spectrum antibacterial activity against all the bacterial strains. Moreover, compound 5m is found to be the most potent antibacterial and antifungal agent. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggest that potent antimicrobial activity of 5j-m is accompanied by low level of cytotoxicity.
Page(s): 965-973
URI: http://nopr.niscair.res.in/handle/123456789/44748
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(07) [July 2018]

Files in This Item:
File Description SizeFormat 
IJCB 57B(7) 965-973.pdfMain Article205.9 kBAdobe PDFView/Open
IJCB 57B(7) 965-973_Suppl Data.pdfSupplementary Data336.39 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.