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Title: Anti-cervical cancer and anti-metastatic effects of sub-fraction 1a of Solanum nigrum L.
Authors: Li, Jian
Niu, Ruixu
Dong, Lixin
Gao, Liming
Fu, Zhanzhao
Shi, Ming
Li, Kun
Keywords: Polysaccharides;Solanum nigrum L.;Anti-cervical cancer;Anti-metastasis;Antioxidant;LDH
Issue Date: Jul-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, C08B, C08L 1/00- C08L 5/00, A61P 19/00, A61P 21/00, A61K 39/395, C09K 15/00, A01D 4/04
Abstract: In the present study, the crude polyssaccharides from Solanum nigrum L. was fractioned by DEAE-cellulose column chromatography, and was further purified by Sephadex-100 column chromatography. We investigated the anti-cervical cancer activity and anti-metastasis effects of the sub-fraction 1a of polysaccharides from Solanum nigrum L. (SNL-P1a) in tumor-bearing mice models, and explored the probable mechanism underlying the pharmacological activity of the polysaccharide. Mice were grouped into the model control, positive control and SNL-P1a of low and high dose treatment groups. After experiment ended, the tumor growth and the lung metastasis inhibition rates were calculated respectively. Furthermore, the serum antioxidant enzyme activities in mice were measured by spectrophotometer method. Results showed that SNL-P1a inhibited the growth and the metastasis of cervical cancer significantly. Moreover, SNL-P1a treatment increased serum antioxidant enzyme activity and LDH activity. These results suggested that the antioxidant activity of SNL-P1a might be beneficial to the cervical cancer therapy.
Page(s): 437-444
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(3) [July 2018]

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