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Title: A facile and simple synthesis of novel isoxazolyl benzo[f][1,4]oxazepin-3-(2H)-ones and their antimicrobial activity
Authors: Kakkerla, Ramu
Marri, Srinivas
Krishna, M P S Murali
Rajam, M V
Keywords: Isoxazolyl benzo[f][1,4]-oxazepin-3-(2H)-ones;Oxazepins;Reductive amination;Antimicrobial activity
Issue Date: Jun-2018
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel isoxazolyl benzo[f][1,4]oxazepin-3-(2H)-ones (9a-h) have been synthesized by adopting a facile and simple methodology. The reaction of 3-amino-5-methylisoxazole (5) with salicylaldehydes (6), followed by reduction with NaBH4, and in situ chloroacetylation and cyclization with chloroacetyl chloride and triethyl amine affords isoxazolyl benzo[f][1,4]oxazepin-3-(2H)-ones (9a-h). The newly synthesized compounds (7-9) have been characterized by spectral (IR, 1H and 13C NMR, and HRMS) data. The title compounds (9a-h) have been evaluated for their in vitro antimicrobial activity against different bacterial and fungal strains. Compounds 9b, 9f and 9g show excellent antimicrobial activity, when compared to the respective standard drugs.
Page(s): 823-829
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(06) [June 2018]

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