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Title: Inhibition of MAO and GABA: Probable mechanisms for antidepressant-like activity of <i style="">Nardostachys jatamansi</i> DC. in mice
Authors: Dhingra, Dinesh
Goyal, Parveen Kumar
Keywords: Depression
Forced swim test
Monoamine oxidase
<i style="">Nardostachys jatamansi</i>
Tail suspension test
Issue Date: Apr-2008
Publisher: CSIR
Abstract: Ethanolic extract (100, 200 and 400 mg/kg, po) of <i style="">N. jatamansi </i>administered for 14 successive days to Swiss young albino mice (either sex) produced significant antidepressant-like effect in both tail suspension and forced swim tests. The efficacy of the extract was found to be comparable to imipramine (15 mg/kg, po) and sertraline (20 mg/kg, po). Ethanolic extract (200 mg/kg, po) did not show any significant change on locomotor activity of mice as compared to control; hence it did not produce any motor effects. Further, the extract decreased the whole brain MAO-A and MAO-B activities as compared to control, thus increased the levels of monoamines. The antidepressant effect of the extract was also significantly reversed by pretreatment of animals with baclofen (GABA<sub>B</sub> agonist); when tested in tail suspension test. The results suggested that the antidepressant-like effect of the extract may also be due to interaction with GABA<sub>B</sub> receptors, resulting in decrease in the levels of GABA in mouse brain. Thus, the extract may have potential therapeutic value for the management of mental depression.
Description: 212-218
ISSN: 0019-5189
Appears in Collections:IJEB Vol.46(04) [April 2008]

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