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IJEB Vol.46(03) [March 2008] >


Title: CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino rats
Authors: Das, Sutapa
Guha, Debjani
Keywords: Anticonvulsant
Epilepsy
Neurotransmitters
PTZ
Spinacia oleracea
Issue Date: Mar-2008
Publisher: CSIR
Abstract: Treatment with Spinacia oleracea extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudate nucleus, midbrain and pons and medulla. Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas.
Page(s): 185-190
ISSN: 0019-5189
Source:IJEB Vol.46(03) [March 2008]

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