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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(03) [March 2008] >
| Title: | Gabapentin attenuates acute hypoxic stress–induced behavioral alterations and oxidative damage in mice: Possible involvement of GABAergic mechanism |
| Authors: | Kumar, Anil
Goyal, Richa |
| Keywords: | Anxiety
Gabapentin
Hypoxic stress
Lipid peroxidation
Locomotor activity
Muscimol
Picrotoxin |
| Issue Date: | Mar-2008 |
| Publisher: | CSIR |
| Abstract: | The effect of gabapentin has been investigated on acute hypoxic stress-induced behavioral alterations and oxidative damage in mice. Mice were subjected to hypoxia for 2 hr. Treatment with gabapentin (50 and 100 mg/kg) significantly increased ambulatory movements, exerted anti-anxiety like effect and reduced oxidative damage in mice subjected to acute hypoxic stress. Treatment with picrotoxin (1.0 mg/kg) per se had no significant effect on behavioral and biochemical parameters of stressed mice. Treatment with muscimol (0.05 mg/kg) per se significantly increased the locomotor activity of stressed mice, exerted significant anti anxiety effect and significantly reduced the oxidative damage. Further, pretreatment with picrotoxin (1.0 mg/kg) significantly blocked whereas pretreatment with muscimol (0.05 mg/kg) significantly potentiated the neuroprotective effect of gabapentin. These results suggest that gabapentin produces its neuroprotective effect in mice subjected to acute hypoxic stress through GABAA receptor mechanism. |
| Page(s): | 159-163 |
| ISSN: | 0019-5189 |
| Source: | IJEB Vol.46(03) [March 2008]
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