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|Title:||Gabapentin attenuates acute hypoxic stress–induced behavioral alterations and oxidative damage in mice: Possible involvement of GABAergic mechanism|
|Keywords:||Anxiety;Gabapentin;Hypoxic stress;Lipid peroxidation;Locomotor activity;Muscimol;Picrotoxin|
|Abstract:||The effect of gabapentin has been investigated on acute hypoxic stress-induced behavioral alterations and oxidative damage in mice. Mice were subjected to hypoxia for 2 hr. Treatment with gabapentin (50 and 100 mg/kg) significantly increased ambulatory movements, exerted anti-anxiety like effect and reduced oxidative damage in mice subjected to acute hypoxic stress. Treatment with picrotoxin (1.0 mg/kg) per se had no significant effect on behavioral and biochemical parameters of stressed mice. Treatment with muscimol (0.05 mg/kg) per se significantly increased the locomotor activity of stressed mice, exerted significant anti anxiety effect and significantly reduced the oxidative damage. Further, pretreatment with picrotoxin (1.0 mg/kg) significantly blocked whereas pretreatment with muscimol (0.05 mg/kg) significantly potentiated the neuroprotective effect of gabapentin. These results suggest that gabapentin produces its neuroprotective effect in mice subjected to acute hypoxic stress through GABAA receptor mechanism.|
|Appears in Collections:||IJEB Vol.46(03) [March 2008]|
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