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Title: Efficiency of propolis extract against mitochondrial stress induced by antineoplasic agents (doxorubicin and vinblastin) in rats
Authors: Benguedouar, Lamia
Boussenane, Hanane Nadia
Kebsa, Wided
Alyane, Mohamed
Rouibah, Hassiba
Lahouel, Mesbah
Keywords: Doxorubicin;Heart;Liver;Lipid peroxidation;Propolis extract;Vinblastin
Issue Date: Feb-2008
Publisher: CSIR
Abstract: To assess the oxidative stress and mitochondrial dysfunction associated with disease, toxic process and aging, in vivo and in vitro preventive effect of propolis extract against mitochondrial oxidative stress induced by two anticancer drugs (doxorubicin and vinblastin) have been investigated in female wistar rat using liver and heart mitochondria. The results show that doxorubicin and vinblastin altered mitochondrial functions as observed by a decrease in respiratory control value, an activation of swelling and overproduction of superoxide anion. Myocardial tissue from doxorubicin treated rats showed a marked increase in malondialdehyde production, a depletion of reduced glutathione contents and an inhibition of catalase and superoxide dismutase activities. Similar results were also observed in liver tissue. Pretreatment of rats with propolis extract (100 mg/kg/day po) (10-4 M ip) administered 4 days prior to doxorubicin (20 mg/kg) and/or vinblastin (2 mg/kg) injection, substantially reduced the peroxidative damage in myocardium and hepatic tissues and markedly restored the tissues catalase and SOD activities. The results strongly suggest that propolis extract protects heart and liver tissues from oxidative stress by protecting the mitochondria.
Page(s): 112-119
ISSN: 0019-5189
Appears in Collections:IJEB Vol.46(02) [February 2008]

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