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Title: Lycopene ameliorates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rat
Authors: Kuhad, Anurag
Chopra, Kanwaljit
Keywords: Diabetic neuropathy;Hyperalgesia;Lycopene;Oxidative stress
Issue Date: Feb-2008
Publisher: CSIR
Abstract: Peripheral neuropathy is one of the common complications of diabetes mellitus. It is frequently associated with debilitating pain. The present study was designed to investigate effect of Lycopene, a carotenoid found in tomatoes, on hyperalgesia and cold allodynia in streptozotocin (STZ) induced diabetic rats. After 4-weeks of STZ injection, diabetic mice exhibited a significant thermal hyperalgesia cold allodynia, hyperglycemia and loss of body weights as compared with control rats. Chronic treatment of lycopene for 4 weeks significantly attenuated the cold allodynia and thermal hyperalgesia. The results emphasize the role of antioxidant such as lycopene as an adjuvant therapy in the treatment of diabetic neuropathy.
Page(s): 108-111
ISSN: 0019-5189
Appears in Collections:IJEB Vol.46(02) [February 2008]

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