Please use this identifier to cite or link to this item:
|Title:||Lycopene ameliorates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rat|
|Keywords:||Diabetic neuropathy;Hyperalgesia;Lycopene;Oxidative stress|
|Abstract:||Peripheral neuropathy is one of the common complications of diabetes mellitus. It is frequently associated with debilitating pain. The present study was designed to investigate effect of Lycopene, a carotenoid found in tomatoes, on hyperalgesia and cold allodynia in streptozotocin (STZ) induced diabetic rats. After 4-weeks of STZ injection, diabetic mice exhibited a significant thermal hyperalgesia cold allodynia, hyperglycemia and loss of body weights as compared with control rats. Chronic treatment of lycopene for 4 weeks significantly attenuated the cold allodynia and thermal hyperalgesia. The results emphasize the role of antioxidant such as lycopene as an adjuvant therapy in the treatment of diabetic neuropathy.|
|Appears in Collections:||IJEB Vol.46(02) [February 2008]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.