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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(02) [February 2008] >
| Title: | Lycopene ameliorates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rat |
| Authors: | Kuhad, Anurag
Chopra, Kanwaljit |
| Keywords: | Diabetic neuropathy
Hyperalgesia
Lycopene
Oxidative stress |
| Issue Date: | Feb-2008 |
| Publisher: | CSIR |
| Abstract: | Peripheral neuropathy is one of the common complications of diabetes mellitus. It is frequently associated with debilitating pain. The present study was designed to investigate effect of Lycopene, a carotenoid found in tomatoes, on hyperalgesia and cold allodynia in streptozotocin (STZ) induced diabetic rats. After 4-weeks of STZ injection, diabetic mice exhibited a significant thermal hyperalgesia cold allodynia, hyperglycemia and loss of body weights as compared with control rats. Chronic treatment of lycopene for 4 weeks significantly attenuated the cold allodynia and thermal hyperalgesia. The results emphasize the role of antioxidant such as lycopene as an adjuvant therapy in the treatment of diabetic neuropathy. |
| Page(s): | 108-111 |
| ISSN: | 0019-5189 |
| Source: | IJEB Vol.46(02) [February 2008]
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