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Title: Kinetic and mechanistic studies of oxidation of chloramphenicol by sodium metaperiodate using Rh(III)-chloride as homogeneous catalyst
Authors: Pradhan, Ranju
Srivastava, Jaya
Bala, Ritu Swamini
Yadav, Rupam
Rahmani, Shahla
Singh, Ashok Kumar
Keywords: Kinetics;Reaction mechanism;Oxidation;Rhenium;Chloramphenicol
Issue Date: Apr-2018
Publisher: NISCAIR-CSIR, India
Abstract: The kinetics of oxidation of an antibiotic drug, chloramphenicol (CHP) by NaIO4 in the presence of Rh(III) catalyst has been investigated in alkaline medium at 35 °C. The reaction shows first order kinetics with respect to [IO4-] and [Rh(III)]. The fractional positive order kinetics in [OH-] and [CHP] throughout their variations are observed. Ionic strength and dielectric constant of the medium show no effects on the reaction rates. No effect of [Cl-] is observed in the presence of Rh(III) chloride. The values of rate constants observed at four different temperatures have been utilized to calculate various activation parameters. The species IO4- and [RhCl3(H2O)2OH]- are proposed as the reactive species of NaIO4 and Rh(III) respectively in alkaline medium. On the basis of kinetic results, spectroscopic information and activation parameters, a suitable mechanism and rate law for the oxidation of CHP has been proposed.
Page(s): 477-484
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.57A(04) [April 2018]

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