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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(02) [February 2007] >
| Title: | Synthesis and antimicrobial investigation of some novel phenyl pyrazole, azetidinone and diazenyl ethanone derivatives of benzofurans |
| Authors: | Kumar, D B Aruna
Prakash, G K
Kumaraswamy, M N
Nandeshwarappa, B P |
| Keywords: | Substituted phenyl pyrazole
Azetidinone
Diazenyl ethanone derivatives
Benzofuran
Antimicrobial activity |
| Issue Date: | Feb-2008 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.⁸ C 07 D |
| Abstract: | Salicylaldehyde and 2-hydroxy acetophenone on reaction with chloroacetone afford corresponding benzofurans 2a, 2b respectively. The compounds 2a and 2b on treatment with phenyl hydrazine in ethanol give 3a-d. The products 3a-d on treatment with DMF/POCl₃ underwent cyclization to produce substituted pyrazoles 4a-d. The compounds 2a-b on treatment with aromatic amines in ethanol afford the corresponding Schiff’s bases 5a-h, which on treatment with chloroacetyl chloride in dioxane produced azetidinones 6a-h. Further, the compounds 2a and 2b on reaction with various diazotized aromatic amines produce phenyl diazenyl benzofurans 7a-h. The structure of all newly synthesized compounds are established by elemental analysis and spectral studies. Their antimicrobial activities have been evaluated. |
| Page(s): | 336-343 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(02) [February 2007]
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