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Title: Synthesis and antimicrobial investigation of some novel phenyl pyrazole, azetidinone and diazenyl ethanone derivatives of benzofurans
Authors: Kumar, D B Aruna
Prakash, G K
Kumaraswamy, M N
Nandeshwarappa, B P
Keywords: Substituted phenyl pyrazole;Azetidinone;Diazenyl ethanone derivatives;Benzofuran;Antimicrobial activity
Issue Date: Feb-2008
Publisher: CSIR
IPC Code: Int.Cl.⁸ C 07 D
Abstract: Salicylaldehyde and 2-hydroxy acetophenone on reaction with chloroacetone afford corresponding benzofurans 2a, 2b respectively. The compounds 2a and 2b on treatment with phenyl hydrazine in ethanol give 3a-d. The products 3a-d on treatment with DMF/POCl₃ underwent cyclization to produce substituted pyrazoles 4a-d. The compounds 2a-b on treatment with aromatic amines in ethanol afford the corresponding Schiff’s bases 5a-h, which on treatment with chloroacetyl chloride in dioxane produced azetidinones 6a-h. Further, the compounds 2a and 2b on reaction with various diazotized aromatic amines produce phenyl diazenyl benzofurans 7a-h. The structure of all newly synthesized compounds are established by elemental analysis and spectral studies. Their antimicrobial activities have been evaluated.
Page(s): 336-343
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(02) [February 2007]

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