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Title: Immunostimulatory action of AC II — An ayurvedic formulation useful in HIV
Authors: Tharakan, Sheeja T
Kuttan, Girija
Kuttan, Ramadasan
Keywords: Cell mediated immunity;Cytotoxic T lymphocytes;Herbal drugs;Humoral immunity;Traditional medicine
Issue Date: Jan-2008
Publisher: CSIR
Abstract: Immunostimulatory activity of AC II, a registered ayurvedic preparation prepared at Amala Ayurvedic Research Centre for treating HIV and AIDS is reported. AC II administration could significantly enhance the mitogen-induced proliferation of lymphocytes of spleen cells. It was also found to increase cell-mediated immune responses in normal and tumor-bearing control animals. Oral administration of AC II significantly enhanced Natural Killer cell activity in normal and tumor-bearing animals on the 7th day, which was observed earlier than the tumor-bearing control animals and normal animals. Antibody dependent cellular cytotoxicity (ADCC) was also increased in AC II treated normal and tumor-bearing animals. An early enhancement of antibody-dependent complement-mediated cytotoxicity was also observed by the administration of AC II in normal as well as tumor-bearing animals. Treatment with AC II elevated the levels of IL-2, TNF-a and IFN-g in normal mice. Administration of AC II was also found to increase the cytotoxic T lymphocyte production in EL4 treated mice. These studies support the use of this immune stimulatory preparation in HIV patients.
Page(s): 47-51
ISSN: 0019-5189
Appears in Collections:IJEB Vol.46(01) [January 2008]

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