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|Title:||Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells-An <i style="">in vitro</i> study|
|Abstract:||Tumor cells intensely utilize glutamine as the major source of respiratory fuel. Glutamine-analogue acivicin inhibits tumor growth and tumor-induced angiogenesis in Ehrlich ascites carcinoma. In the present study, antitumor properties of acivicin in combination with glutaminase enzyme is reported. Acivicin along with <i style="">E. coli</i> glutaminase synergistically reduced <i style="">in vitro</i> proliferation and matrigel invasion of human MCF-7 and OAW-42 cells. Effects of single and combined treatments with acivicin and glutaminase on angiogenic factors were also analyzed in these cell lines. Co-administration of the treatment agents inhibits the release of VEGF and MMP-9 by cells in culture supernatant significantly than single agent treatments. The result suggests that combination of acivicin with glutaminase may provide a better therapeutic option than either of them given separately for treating human breast and ovarian cancer. However, further studies are required to be conducted <i style="">in vivo</i> for its confirmation.|
|Appears in Collections:||IJEB Vol.46(01) [January 2008]|
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