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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(01) [January 2007] >
| Title: | Conformational studies of some N-acyl-t(3)-isopropyl-r(2), c(6)-bis-(2'-furyl)piperidin-4-ones |
| Authors: | Manimekalai, A
Selvaraju, K
Maruthavanan, T |
| Keywords: | NMR spectra
Molecular conformation
N-acyl-piperidin-4-ones |
| Issue Date: | Jan-2007 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.⁸ C07D |
| Abstract: | The high resolution ¹H and ¹³C NMR spectra of four N-acyl-t(3)-isopropyl-r(2),c(6)-bis(2¢-furyl)piperidin-4-ones 1-4 have been recorded at various temperatures and analysed. The spectra reveal the presence of two rotameric forms (E and Z) in solution. ¹H-¹H COSY spectra for 1-4 and ¹H-¹³C COSY spectrum for 4 have been recorded to assist the assignment of the signals for the E and Z isomers of 1-4. Coupling constants predict an equilibrium mixture of boat form B₁ and alternate chair form CA for 1-4. The effect of varying the substituents at nitrogen on the ¹H and ¹³C chemical shifts have been analysed in detail. Mass spectra have also been recorded for 1-5. |
| Page(s): | 160-169 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(01) [January 2007]
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