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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(06) [June 2009] >
| Title: | Cross-resistance of Mycobacterium tuberculosis isolates among streptomycin, kanamycin and amikacin |
| Authors: | Sugawara, I
Zhang, J
Li, C |
| Keywords: | Amikacin
Cross-resistance
Kanamycin
MDR-TB
Streptomycin |
| Issue Date: | Jun-2009 |
| Publisher: | CSIR |
| Abstract: | Seventy-four streptomycin (SM)-resistant M. tuberculosis clinical isolates were subjected to cross-resistance drug testing against two major aminoglycosides, kanamycin (KM) and amikacin (AMK). Among them, 15 clinical isolates (20.3%) were resistant to both KM and AMK. Fifteen (80%) of 19 KM-resistant isolates were AMK-resistant. Fifteen SM, KM, and AMK resistant isolates harbored rrs mutation, but only two had rrs and rpsL double mutations. Low-level SM resistance was associated with rpsL mutation, whereas high-level SM resistance was linked to rrs mutation. |
| Page(s): | 520-522 |
| ISSN: | 0019-5189 |
| Source: | IJEB Vol.47(06) [June 2009]
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