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IJEB Vol.47(06) [June 2009] >


Title: Cross-resistance of Mycobacterium tuberculosis isolates among streptomycin, kanamycin and amikacin
Authors: Sugawara, I
Zhang, J
Li, C
Keywords: Amikacin
Cross-resistance
Kanamycin
MDR-TB
Streptomycin
Issue Date: Jun-2009
Publisher: CSIR
Abstract: Seventy-four streptomycin (SM)-resistant M. tuberculosis clinical isolates were subjected to cross-resistance drug testing against two major aminoglycosides, kanamycin (KM) and amikacin (AMK). Among them, 15 clinical isolates (20.3%) were resistant to both KM and AMK. Fifteen (80%) of 19 KM-resistant isolates were AMK-resistant. Fifteen SM, KM, and AMK resistant isolates harbored rrs mutation, but only two had rrs and rpsL double mutations. Low-level SM resistance was associated with rpsL mutation, whereas high-level SM resistance was linked to rrs mutation.
Page(s): 520-522
ISSN: 0019-5189
Source:IJEB Vol.47(06) [June 2009]

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