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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(06) [June 2009] >
| Title: | Mycobacterium tuberculosis secreted antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases |
| Authors: | Basu, Sandip Kumar
Kumar, Dhiraj
Ganguly, Niladri
Rao, Kanury Venkata Subba
Sharma, Pawan |
| Keywords: | Antigenic (MTSA-10)
Lipopolysaccharide
Macrophage
Mycobacterium tuberculosis
Phosphatase
Redox regulation |
| Issue Date: | Jun-2009 |
| Publisher: | CSIR |
| Abstract: | The present study was undertaken to investigate the possible role of a 10-kDa, secretory antigenic protein of Mtb (MTSA-10) in regulating macrophase response to lipopolysacchride (LPS). MTSA-10 inhibited the lipopolysaccharide (LPS)-induced oxidant species generation in the macrophage. Treatment of macrophages with MTSA-10 activated their protein tyrosine phosphatases (PTPs) in a redox-regulated fashion. These activated phosphatases then interfered with the early events of LPS signaling and lower the strength and magnitude of the signal generated, thereby preventing macrophages from making an effective immune response. Mycobacterium tuberculosis Region of Deletion-1 (RD-1)-specific secretory antigen MTSA-10 (encoded by ORF Rv3874 of Mtb genome) modulated the macrophage signaling machinery and prevented it from responding to further activation by LPS. |
| Page(s): | 505-519 |
| ISSN: | 0019-5189 |
| Source: | IJEB Vol.47(06) [June 2009]
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