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Title: Mycobacterium tuberculosis secreted antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases
Authors: Basu, Sandip Kumar
Kumar, Dhiraj
Ganguly, Niladri
Rao, Kanury Venkata Subba
Sharma, Pawan
Keywords: Antigenic (MTSA-10);Lipopolysaccharide;Macrophage;Mycobacterium tuberculosis;Phosphatase;Redox regulation
Issue Date: Jun-2009
Publisher: CSIR
Abstract: The present study was undertaken to investigate the possible role of a 10-kDa, secretory antigenic protein of Mtb (MTSA-10) in regulating macrophase response to lipopolysacchride (LPS). MTSA-10 inhibited the lipopolysaccharide (LPS)-induced oxidant species generation in the macrophage. Treatment of macrophages with MTSA-10 activated their protein tyrosine phosphatases (PTPs) in a redox-regulated fashion. These activated phosphatases then interfered with the early events of LPS signaling and lower the strength and magnitude of the signal generated, thereby preventing macrophages from making an effective immune response. Mycobacterium tuberculosis Region of Deletion-1 (RD-1)-specific secretory antigen MTSA-10 (encoded by ORF Rv3874 of Mtb genome) modulated the macrophage signaling machinery and prevented it from responding to further activation by LPS.
Page(s): 505-519
ISSN: 0019-5189
Appears in Collections:IJEB Vol.47(06) [June 2009]

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