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Title: Anti-IL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide
Authors: Bhattacharjee, Surajit
Gupta, Gaurav
Bhattacharya, Parna
Adhikari, Anupam
Majumdar, Suchandra Bhattacharya
Majumdar, Subrata
Keywords: Anti-IL-10 monoclonal antibody;Leishmaniasis;Nitric oxide;Th1/Th2 cells
Issue Date: Jun-2009
Publisher: CSIR
Abstract: Visceral leishmaniasis is characterized by severe immune suppression of the host. This suppression of the host immune system is primarily mediated by the immunosuppressive cytokine Interleukin-10 (IL-10), whose levels are significantly up-regulated during leishmaniasis. This immune suppression is reflected at the level of T-cell dysfunction and abrogation of leishmaniacidal molecules along with a dampened Th1 cytokine response. In the present study, we showed in vivo neutralization of IL-10 by administration of anti IL-10 monoclonal antibodies (mAb) could confer protection against leishmanial pathogenesis. This protective response was primarily mediated by a strong induction of T cell proliferation along with a Th1 biased cytokine response which was further aided by the generation of, leishmanicidal molecules, nitric oxide.
Page(s): 489-497
ISSN: 0019-5189
Appears in Collections:IJEB Vol.47(06) [June 2009]

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