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Title: Synthesis and antimicrobial activity of 5-amino-2,7- diaryl-6-cyano- 3-isonicotinamido thiazolo [4,5-b]-2,3,4,7- tetrahydropyridines, 2,7-diaryl-6-cyano-3- isonicotinamido thiazolo [4,5-b]-2,3,4,5,6,7- hexahydropyrid-5-ones, 2,7-diaryl-5-amino-3- isonicotinamido thiazolo [4,5-d][1,3-]thiazines and 2,6-diaryl-3- isonicotinamido thiazolo[4,5-c] pyrazolines
Authors: Khan, Mukhtar Hussain
Keywords: Thiazolo[4,5-b]pyridines;Thiazolo[4,5-b]pyridones;Thiazolo- [4,5-d][1,3]thiazines;Thiazolo[4,5-c]pyrazolines;Bactericidal;Fungicial activity
Issue Date: Jan-2007
Publisher: CSIR
IPC Code: Int.Cl.⁸ C07D
Abstract: 5-Amino-2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,7-tetrahydropyridines 3 and 2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,5,6,7-hexahydropyrid-5-ones 4 have been prepared by Michael addition between ⍺,β-unsaturated ketones 2 and malononitrile/ethyl cyanoacetate in the presence of excess ammonium acetate. 2,7-Diaryl-5-amino-3-isonicotinamido thiazolo[4,5-d][1,3]thiazines 5 and 2,6-diaryl-3-isonicotinamido thiazolo[4,5-c]pyrazolines 6 have been prepared by cyclocondensation of ⍺,β-unsaturated ketones 2 with thiourea/hydrazine hydrate, respectively. The antimicrobial activity of the representative samples are assayed against bacteria E. coli, B. subtilis, S. aureus and fungi A. niger, P. oryzae and F. oxysporum at 100 μg/mL concentration.
Page(s): 148-153
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(01) [January 2007]

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