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dc.contributor.authorOrme, Ian M-
dc.description.abstractTesting of new vaccines in animal models has certain advantages and disadvantages. As we better understand the complexity of the immune response to vaccines, new information may be complicating the assessment of the efficacy of new candidate vaccines. Four possible complications are discussed here, (i) induction of Foxp3+ T cells; (ii) induction of memory T cell subsets; (iii) location of extracellular organisms in lung necrosis; and (iv) protection against isolates of high/extreme immunopathology.en_US
dc.sourceIJEB Vol.47(06) [June 2009]en_US
dc.subjectAnimal modelen_US
dc.subjectFoxp3+ cellsen_US
dc.subjectLung necrosisen_US
dc.subjectTB vaccineen_US
dc.subjectT cellen_US
dc.titlePotential complications to TB vaccine testing in animal modelsen_US
Appears in Collections:IJEB Vol.47(06) [June 2009]

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