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IJEB Vol.47(06) [June 2009] >

Title: Potential complications to TB vaccine testing in animal models
Authors: Orme, Ian M
Keywords: Animal model
Foxp3+ cells
Lung necrosis
TB vaccine
T cell
Issue Date: Jun-2009
Publisher: CSIR
Abstract: Testing of new vaccines in animal models has certain advantages and disadvantages. As we better understand the complexity of the immune response to vaccines, new information may be complicating the assessment of the efficacy of new candidate vaccines. Four possible complications are discussed here, (i) induction of Foxp3+ T cells; (ii) induction of memory T cell subsets; (iii) location of extracellular organisms in lung necrosis; and (iv) protection against isolates of high/extreme immunopathology.
Page(s): 440-444
ISSN: 0019-5189
Source:IJEB Vol.47(06) [June 2009]

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