Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/43658
Title: Antioxidant and anti-inflammatory effects of Acrocarpus fraxinifolius on hyperglycemia, hyperlipidemia and liver/kidney dysfunctions against alloxan induced Type 1 diabetes in rats
Authors: El-Ghffar, Eman Ali Abd
Shehata, Safia Mohamed
Keywords: Acrocarpus fraxinifolius;Alloxan;Antioxidant;Cytokines;Diabetes
Issue Date: Apr-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61K38/28, A61K 38/00, C09K 15/00, A61K 38/19, C12N 15/19, A01D 16/02
Abstract: Many factors such as oxidative stress and pro-inflammatory cytokines cause β-cell dysfunction and death. The aim of this study was to investigate antioxidant and anti-inflammatory effects of Acrocarpus fraxinifolius (A. fraxinifolius) on hyperglycemia, hyperlipidemia and liver/kidney dysfunctions against alloxan induced Type 1 diabetes in rats. Thirty six male white albino rats were divided into 6 groups: Control group, diabetic group and two prophylactic group with two different doses and two therapeutic group with two different doses (250 or 500 mg/kg b.w; for 28 consecutive days). Diabetes was induced by i.p. injection of 75 mg/kg b.walloxan monohydrate for 5 consecutive days. In this study showed that A. fraxinifolius extract [especially prophylactic treatment] significantly suppressed diabetic complications in alloxan-induced diabetes in rat model by alleviating body weight loss, hyperglycemia, hypo-insulinemia and dyslipidemia through activating the antioxidant defense system, decreasing of oxidative/nitrosative stress as well as lipid peroxidation, and increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines, respectively. The percentage of disease recovery was 15.00 ± 5.472 % in high dose A. fraxinifolius of prophylactic treatment compared with alloxan only group 73.70 ± 22.09 % (p < 0.05).The data confirmed property of A. fraxinifolius as an antioxidant and anti-inflammatory that ameliorates oxidative/nitrosative stress and revealed that it is efficiently improves diabetic complication in alloxan-induced diabetic rats.
Page(s): 223-232
URI: http://nopr.niscair.res.in/handle/123456789/43658
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(2) [April 2018]

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