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Title: Purification of Guggul by Ayurvedic process (Shodhana), estimation of Guggulsterone E & Z before and after purification by HPLC analysis
Authors: Pal, Prince Kumar
Prasad, Goli Penchala
Babu, Gajji
Gautam, Dev Nath Singh
Singh, Narendra Kumar
Keywords: Guggul;Shodhana;Guggulsterone E & Z;HPLC
Issue Date: Apr-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61K 9/00, A61K 45/06, B01D 53/34, A61K 39/395, C07D 457/14
Abstract: Guggul is one of the Ayurvedic product in great demand, used for over thousands of years and high status for its versatile use in several ailments. The two most important pharmacological properties of guggul are its anti-inflammatory and hypolipidaemic actions. The present study was undertaken to find out the effect of three different media of purification (water, cow’s urine and Triphala Kashay a (decoction of three myrobalans)) of raw guggul on its markers Guggulsterone E & Z at different heating temperature during Shodhana (purification) process. The guggul purified by different methods was found to be quite variable in reference to physico-chemical parameters and its marker compounds Guggulsterone E & Z by HPLC analysis at similar chromatographic conditions. The Guggulsterone E & Z was found in the order: water > cow’s urine > Triphla Kashaya (0.29 w/w, 0.24 w/w and 0.16 w/w, respectively at 85 °C to 95 °C). But the same raw guggul purified with same media like water, cow’s urine and Triphala Kashay a at temperature 60 °C to 70 °C showed the presence of high quantity of Guggulsterone E & Z (0.49 w/w, 0.45 w/w and 0.30 w/w for water, cow’s urine and Triphala Kashay a, respectively), as compared to the quantity of Guggulsterone E & Z found at temperature 85 °C to 95 °C.
Page(s): 391-395
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(2) [April 2018]

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