NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(06) [June 2009] >


Title: cAMP signaling in Mycobacterium tuberculosis
Authors: Agarwal, Nisheeth
Bishai, William R
Keywords: Adenylate cyclase
CREB
Cyclic AMP
Mycobacterium tuberculosis
Phosphodiesterase
Signal transduction
Virulence
Issue Date: Jun-2009
Publisher: CSIR
Abstract: cAMP is an important second messenger in both eukaryotic and prokaryotic organisms. Several bacterial pathogens have developed mechanisms to subvert eukaryotic cAMP signaling by injecting protein toxins that are themselves adenylate cyclases or by introducing toxins that modify host adenylate cyclases to an overexpression state. Curiously, Mycobacterium tuberculosis CDC1551 genome contains seventeen adenylate cyclase homologues suggesting that cAMP signaling is both relevant and complex in biology of M. tuberculosis. The present article provides an overview of the role of cAMP as a second messenger, discusses bacterial cAMP subversion mechanisms, and reviews the evidence currently available on cAMP-based signaling in M. tuberculosis.
Page(s): 393-400
ISSN: 0019-5189
Source:IJEB Vol.47(06) [June 2009]

Files in This Item:

File Description SizeFormat
IJEB 47(6) 393-400.pdf74.82 kBAdobe PDFView/Open
 Current Page Visits: 943 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 570133 since 06-Feb-2009  Last updated on 14-Aug-2014Webmaster: nopr@niscair.res.in