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Title: Synthesis and biological activities of nicotinaldehyde based azlactones
Authors: Dayakar, Ch
Mounika, L
Rajkumar, K
Zehra, A
Murthy, T R
Kalivendi, Shasi V
Tiwari, A K
Raju, B China
Keywords: Nicotinaldehydes;Azlactones;DPPH;ABTS+.radical scavenging activity;α-glucosidase inhibition;Anti-proliferative activity
Issue Date: Jan-2018
Publisher: NISCAIR-CSIR, India
Abstract: A series of nicotinaldehyde based azlactones 3a-g, 6a-f, 11a-d, 16b-c, and 16e-f have been prepared and screened for their free radicals scavenging, α-glucosidase inhibitory and anti-proliferative activities on cell lines, namely lung adenocarcinoma (A549), human breast cancer (MCF7) and human epithelial cervical cancer (HeLa). Compound 3g is the most potent α-glucosidase inhibitor followed by compounds 6b and 6a. Compound 11b is the better DPPH and ABTS+ radical scavenger. Compounds 11c-d and 16f show anti-proliferative activity on all the tested cell lines. However, compounds 16c and 16e display anti-proliferative activity on MCF7 and HeLa cell lines.
Page(s): 98-107
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(01) [January 2018]

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