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Title: Sulfonylurea derivatives of tolbutamide analogues: Synthesis and evaluation of antimicrobial and antioxidant activities
Authors: Ramudu, D B Janaki
Babu, Pulluru Hari
Venkateswarlu, Nagam
Vijaya, Tartti
Rasheed, S
Raju, Chamarthi Naga
Chalapathi, Ponne Venkata
Keywords: Sulfonylurea derivatives;Tolbutamide analogues;Antibacterial;Antifungal activities;Antioxidant activities
Issue Date: Jan-2018
Publisher: NISCAIR-CSIR, India
Abstract: A series of new sulfonylurea derivatives of tolbutamide analogues have been synthesized in a simple and effective way in high yields to explore the possibilities of some altered biological actions such as antibacterial, antifungal and antioxidant activities (DPPH, H2O2 and IC50 values). Structures of these compounds have been well established by IR, 1H and 13C NMR, mass spectra and elemental analysis. Among the compounds 9c and 9j show promising antimicrobial activity. Compounds 9a, 9j and 9d exhibit good antioxidant activity with lowest IC50 values and close to the standard drug, ascorbic acid. Biological data reveals that sulfonylurea derivatives show good antioxidant activity rather than antimicrobial activity.
Page(s): 127-135
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(01) [January 2018]

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