Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/43274
Title: Environmentally benign synthesis and anti-mycobacterial evaluation of 9,10-dihydro-4-methyl-chromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives
Authors: Mathew, Bijoy P
Tandon, Rashmi
Batra, Neha
Agarwal, Drishti
Bose, Mridula
Gupta, Rinkoo D
Nath, Mahendra
Keywords: Anti-mycobacterial activity;Chromeno[8,7-e][1,3]oxazin-2(8H)-ones;Eco-friendly synthesis;Mycobacterium tuberculosis;Toxicity assay
Issue Date: Dec-2017
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, a series of 9,10-dihydro-4-methyl-chromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives (4a-j) have been synthesized by using one-pot Mannich type condensation cyclization reaction of 7-hydroxy-4-methylcoumarin, formaldehyde and primary amines in water at 80-90°C. These products have been characterized using various spectroscopic techniques (1H and 13C NMR, IR, and MS) followed by evaluation of their in-vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv. The compounds 4g and 4h display the lowest MIC of 5 µg/mL and offer a remarkable viability of HEK-293 cells at the highest test concentration (100 μg/mL) in toxicity assay.
Page(s): 1237-1242
URI: http://nopr.niscair.res.in/handle/123456789/43274
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(12) December 2017]

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