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Title: Synthesis and antibacterial activity screening of N- and O-substituted quinolin-2-one acetamide derivatives
Authors: Chand, Karam
Yadav, Preeti
Prasad, Suchita
Sharma, Sunil K
Keywords: Quinolin-2-one acetamide derivatives;Antibacterial potential;Gram +ve/-ve pathogenic strains;Disc diffusion assay
Issue Date: Dec-2017
Publisher: NISCAIR-CSIR, India
Abstract: A series of new quinolin-2-one acetamide derivatives have been synthesized and characterized; their antibacterial potential investigated, against three Gram-positive pathogenic strains namely Bacillus cereus, Bacillus subtilis and Staphylococcus aureus and four Gram-negative pathogenic strains namely Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium and Klebsiella pneumoniae by disc diffusion assay at a concentration of 250 μg/disc. Two of these compounds, which are O-substituted quinolin-2-one acetamides exhibit moderate activity against six bacterial strains B. cereus, B. subtilis, S. aureus, P. aeruginosa, E. coli and S. typhimurium.
Page(s): 1243-1250
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(12) December 2017]

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