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http://nopr.niscair.res.in/handle/123456789/4322
Title: | Voltammetric behaviour of nitrazepam in solubilized systems |
Authors: | Jain, Rajeev Mishra, Ritesh Dwivedi, Ashish |
Keywords: | CV;DPP;Micelles;Nitrazepam;Pharmaceutical formulation;Surfactant |
Issue Date: | Jun-2009 |
Publisher: | CSIR |
Abstract: | Voltammetric behaviour of benzodiazepine tranquilizer drug, nitrazepam, has been studied in acetonitrile using cyclicvoltammetry and differential pulse polarography. Nitrazepam exhibits two well-defined cathodic peaks in acetate buffer (pH3-6). Lower limit of detection (LOD) and lower limit of quantification (LOQ) are found to be 0.47x10-7 and 1.5x10-7 mol l-1respectively. Analysis of nitrazepam in pharmaceutical formulation exhibited mean recoveries of 99.3 % and 99.6 % for bothreduction peaks. Addition of anionic surfactant (sodium lauryl sulphate) to nitrazepam containing electrolyte also exhibit twowell-defined cathodic peaks. Reduction process was irreversible over entire pH range. |
Page(s): | 540-547 |
URI: | http://hdl.handle.net/123456789/4322 |
ISSN: | 0022-4456 |
Appears in Collections: | JSIR Vol.68(06) [June 2009] |
Files in This Item:
File | Description | Size | Format | |
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JSIR 68(6) 540-547.pdf | 151.44 kB | Adobe PDF | View/Open |
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