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JSIR Vol.68 [2009] >
JSIR Vol.68(06) [June 2009] >
| Title: | Voltammetric behaviour of nitrazepam in solubilized systems |
| Authors: | Jain, Rajeev
Mishra, Ritesh
Dwivedi, Ashish |
| Keywords: | CV
DPP
Micelles
Nitrazepam
Pharmaceutical formulation
Surfactant |
| Issue Date: | Jun-2009 |
| Publisher: | CSIR |
| Abstract: | Voltammetric behaviour of benzodiazepine tranquilizer drug, nitrazepam, has been studied in acetonitrile using cyclicvoltammetry and differential pulse polarography. Nitrazepam exhibits two well-defined cathodic peaks in acetate buffer (pH3-6). Lower limit of detection (LOD) and lower limit of quantification (LOQ) are found to be 0.47x10-7 and 1.5x10-7 mol l-1respectively. Analysis of nitrazepam in pharmaceutical formulation exhibited mean recoveries of 99.3 % and 99.6 % for bothreduction peaks. Addition of anionic surfactant (sodium lauryl sulphate) to nitrazepam containing electrolyte also exhibit twowell-defined cathodic peaks. Reduction process was irreversible over entire pH range. |
| Page(s): | 540-547 |
| ISSN: | 0022-4456 |
| Source: | JSIR Vol.68(06) [June 2009]
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