Please use this identifier to cite or link to this item:
Title: Voltammetric behaviour of nitrazepam in solubilized systems
Authors: Jain, Rajeev
Mishra, Ritesh
Dwivedi, Ashish
Keywords: CV;DPP;Micelles;Nitrazepam;Pharmaceutical formulation;Surfactant
Issue Date: Jun-2009
Publisher: CSIR
Abstract: Voltammetric behaviour of benzodiazepine tranquilizer drug, nitrazepam, has been studied in acetonitrile using cyclicvoltammetry and differential pulse polarography. Nitrazepam exhibits two well-defined cathodic peaks in acetate buffer (pH3-6). Lower limit of detection (LOD) and lower limit of quantification (LOQ) are found to be 0.47x10-7 and 1.5x10-7 mol l-1respectively. Analysis of nitrazepam in pharmaceutical formulation exhibited mean recoveries of 99.3 % and 99.6 % for bothreduction peaks. Addition of anionic surfactant (sodium lauryl sulphate) to nitrazepam containing electrolyte also exhibit twowell-defined cathodic peaks. Reduction process was irreversible over entire pH range.
Page(s): 540-547
ISSN: 0022-4456
Appears in Collections:JSIR Vol.68(06) [June 2009]

Files in This Item:
File Description SizeFormat 
JSIR 68(6) 540-547.pdf151.44 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.