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Title: Synthesis, Characterization, Industrial Application and Anticancer Activity of 4-Substituted-2-Oxo-2H-Chromene-3-Carbonitirles Derivatives
Authors: Barasara, A
Pandya, M
Patel, A
Purohit, D
Keywords: 4-Chloro-3-Cyano Coumarin;Aniline Mustard;Anticancer Activity;Spectral Analysis;Nucleophilic Substitution
Issue Date: Dec-2017
Publisher: NISCAIR-CSIR, India
Abstract: A highly efficient strategy to 3, 4-substituted coumarin containing aniline mustard has been developed. The methodology involves nucleophilic substitution of readily accessible 3-substituted 4-chloro coumarin with aniline mustard in the presence of base and IPA as solvent in reflux condition. All synthesized compounds were characterized by IR, NMR and mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer activity. The scope and generality have been discussed.
Page(s): 776-779
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.76(12) [December 2017]

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