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|Title:||Synthesis, Characterization, Industrial Application and Anticancer Activity of 4-Substituted-2-Oxo-2H-Chromene-3-Carbonitirles Derivatives|
|Keywords:||4-Chloro-3-Cyano Coumarin;Aniline Mustard;Anticancer Activity;Spectral Analysis;Nucleophilic Substitution|
|Abstract:||A highly efficient strategy to 3, 4-substituted coumarin containing aniline mustard has been developed. The methodology involves nucleophilic substitution of readily accessible 3-substituted 4-chloro coumarin with aniline mustard in the presence of base and IPA as solvent in reflux condition. All synthesized compounds were characterized by IR, NMR and mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer activity. The scope and generality have been discussed.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.76(12) [December 2017]|
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