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Title: Chemical evaluation of Mucuna species for L-dopa content - an anti-Parkinson’s drug yielding medicinal plant from India
Authors: Raina, Archana P
Misra, RC
Keywords: Mucuna species;Germplasm;HPTLC;L-Dopa;Mucuna pruriens;Parkinson’s disease
Issue Date: Jan-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61K 38/00, A01D 8/46, A01D 8/00
Abstract: Mucuna species is an important medicinal plant of India which is the best known natural source of bioactive compound L-dopa (L-3,4-dihydroxy phenylalanine) used as potential drug for the treatment of Parkinson’s disease. The present study was undertaken for the chemical evaluation of four species of Mucuna, viz.; M. pruriens var. pruriens, M. pruriens var. utilis (Wall. ex Wight) L. H. Bailey, M. monosperma Wight, M. nigricans (Lour.) Steud ., M. gigantea (Willd.) DC., collected from wild habitats of Odisha state of eastern India for pharmaceutically valued compound L-dopa. Results indicated a wide range of germplasm variability in seed size, color and L-dopa content. Among the four Mucuna species, highest L-dopa content was found in M. pruriens var. pruriens germplasm varying between 4.91 % - 7.09 %. Other Mucuna species having high L-dopa were M. gigantea (6.76 %), M. nigricans (6.16 %) and M. monosperma (4.61 %); while M. pruriens var. utilis showed least L-dopa content of 1.22 %. Promising accessions with high L-dopa content (> 6 %) were IC599290, IC599342, IC599336, IC599361 and IC599350. Superior accessions along with other rarely occurring Mucuna species can be exploited for large-scale cultivation of this drug plant for pharmaceutical use.
Page(s): 148-154
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(1) [January 2018]

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