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IJMS Vol.31(2) [June 2002] >


Title: Antimicrobial substances of potential biomedical importance from holothurian species
Authors: Abraham, T. Jawahar
Nagarajan, J.
Shanmugam, S.A.
Keywords: Holothuria spp.
Actinopyga spp.
antimicrobial activity
bioactive substances
human pathogens
Issue Date: Jun-2002
Publisher: CSIR
Abstract: Antibacterial and antifungal activities of alcoholic extracts of holothurian species such as Actinopyga echinites, A. miliaris. Holothuria atra and H. scabra of Tamil Nadu coast were studied. Bacteria such as Aeromonas hydrophila, Escherichia coli, Enterococcus sp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Vibrio harveyi, and fish-borne mold, Aspergillus sp. were inhibited at varying levels by the extracts of A. miliaris, H. atra and H. scabra. Bacillus sp. was not affected by holothurian extracts. The results of the study revealed the presence of antimicrobial substances possibly steroidal sapogenins in holothuria. There exist a great potential for the extraction of bioactive substances of medical importance at a lower cost from marine holothurians.
Page(s): 161-164
ISSN: 0379-5136
Source:IJMS Vol.31(2) [June 2002]

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