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Title: Antimicrobial substances of potential biomedical importance from holothurian species
Authors: Abraham, T. Jawahar
Nagarajan, J.
Shanmugam, S.A.
Keywords: <i>Holothuria</i> spp.
<i>Actinopyga</i> spp.
antimicrobial activity
bioactive substances
human pathogens
Issue Date: Jun-2002
Publisher: CSIR
Abstract: Antibacterial and antifungal activities of alcoholic extracts of holothurian species such as <i>Actinopyga echinites, A. miliaris</i>.<i> Holothuria</i> <i>atra</i> and <i>H. scabra</i> of Tamil Nadu coast were studied. Bacteria such as <i>Aeromonas hydrophila, Escherichia coli, Enterococcus</i> sp., <i>Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus</i> and V<i>ibrio harveyi</i>, and fish-borne mold<i>, Aspergillus</i> sp. were inhibited at varying levels by the extracts of <i>A. miliaris, H. atra</i> and <i>H. scabra</i>. <i>Bacillus</i> sp. was not affected by holothurian extracts. The results of the study revealed the presence of antimicrobial substances possibly steroidal sapogenins in holothuria. There exist a great potential for the extraction of bioactive substances of medical importance at a lower cost from marine holothurians.
Description: 161-164
ISSN: 0379-5136
Appears in Collections:IJMS Vol.31(2) [June 2002]

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