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Title: Synthesis and biological evaluation of novel thiazole and thiadiazole based secondary amines as antibacterial agents
Authors: Sahi, Seema
Paul, Satya
Keywords: N-(4-Substitutedbenzyl)-2-amino-4-aryl-1,3-thiazoles;N-(4-substituted benzyl)-2-amino-5-aryl-1,3,4-thiadiazoles;2-amino-4-aryl-1,3-thiazoles;2-amino-4-substituted-1,3,4-thiadiazoles;Antibacterial activity
Issue Date: Nov-2017
Publisher: NISCAIR-CSIR, India
Abstract: The synthesis of a series of N-(4-substitutedbenzyl)-2-amino-4-aryl-1,3-thiazoles/N-(4-substitutedbenzyl)-2-amino-5-aryl-1,3,4-thiadiazoles has been reported by the reduction of N-(4-substituted benzylidene)-2-amino-4-aryl-1,3-thiazoles/N-(4-substitutedbenzylidene)-2-amino-5-aryl-1,3,4-thiadiazoles with NaBH4, which in turn has been synthesized by the reaction of 2-amino-4-aryl-1,3-thiazoles/2-amino-4-substituted-1,3,4-thiadiazoles with substituted benzaldehydes in the presence of catalytic amount of H2SO4 in good to excellent yields. Synthesized compounds have been evaluated for in vitro antibacterial activity against both Gram-Positive and Gram-Negative bacteria. Some of them exhibit moderate activity in comparison with the standard Ciprofloxacin, such as compound 9a which has shown good antibacterial activity with MIC value of 125 µg/mL against S. aureus and compound 9l which has shown good antibacterial activity with MIC value of 150 µg/mL against E. coli.
Page(s): 1212-1219
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(11) [November 2017]

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