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|Title:||QSAR Modeling of Antimicrobial Activity of some p-substituted Aromatic Hydrazones|
|Keywords:||QSAR;Physicochemical Descriptors;p-substituted Hydrazones|
|Abstract:||QSAR analysis of a series of previously synthesized p-substituted aromatic hydrazones tested for growth inhibitory activity against Bacillus subtilis, was performed using several physicochemical descriptors: Surface tension (ST), Molar Refraction (MR), Molar Volume (MV), Parachor (Pc), Index of Refractivity (η); Density (D) and Polarizability (α). Two-parameter models were obtained and validated by using several statistical parameters: R; R2adj; F-test; Sd; Rped; PRESS/SSY; Q2; SPRESS; PSE and Q. Both the parameters (D and α) contributing to statistically best model (model 16) have positive input to the modeling of biological activity of selected hydrazones.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.76(09) [September 2017]|
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