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Title: QSAR Modeling of Antimicrobial Activity of some p-substituted Aromatic Hydrazones
Authors: Dimova, V
Jankulovska, M
Keywords: QSAR;Physicochemical Descriptors;p-substituted Hydrazones
Issue Date: Sep-2017
Publisher: NISCAIR-CSIR, India
Abstract: QSAR analysis of a series of previously synthesized p-substituted aromatic hydrazones tested for growth inhibitory activity against Bacillus subtilis, was performed using several physicochemical descriptors: Surface tension (ST), Molar Refraction (MR), Molar Volume (MV), Parachor (Pc), Index of Refractivity (η); Density (D) and Polarizability (α). Two-parameter models were obtained and validated by using several statistical parameters: R; R2adj; F-test; Sd; Rped; PRESS/SSY; Q2; SPRESS; PSE and Q. Both the parameters (D and α) contributing to statistically best model (model 16) have positive input to the modeling of biological activity of selected hydrazones.
Page(s): 550-555
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.76(09) [September 2017]

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