Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/42645
Title: Tribulus terrestris ameliorates aluminium chloride–induced alterations in oxidative status and functional markers in the liver, kidney, brain, and testis of the laboratory mouse
Authors: Kumar, Praveen
Singh, Poonam
Keywords: Aluminium Chloride;Antioxidant enzymes;Bindii;Functional markers;Lipid peroxidation;Metal accumulation;Puncture vine;Tackweed
Issue Date: Oct-2016
Publisher: NISCAIR-CSIR, India
Abstract: The ameliorating potential of fruit extract of Tribulus terrestris L. (Tt) against aluminium chloride (AlCl3)-induced alterations in oxidative status and functional markers were studied in the liver, kidney, brain, and testis of the laboratory mouse. Adult male mice were divided into six groups of six each. Group I served as control while that of II - IV received various doses of AlCl3 (25, 50, 100 mg/kg body wt./day, respectively) orally, for 30 days. The mice of groups V and VI were administered with Tt (100 mg/kg body wt./day) only and AlCl3 (100 mg/kg body wt./day) along with Tt (100 mg/kg body wt./day) respectively, for the same duration. Metal estimation, MDA level, the activities of antioxidant enzymes and functional markers were studied in the liver, kidney, brain, and testis. Among three doses of AlCl3, only the high dose (100 mg/kg body wt. for 30 days) caused significant increase in the accumulation of aluminium and MDA level, accompanied by significant decrease in the activities of antioxidant enzymes (SOD, CAT, GPx) in all these organs. AlCl3 at the same dose also caused a significant alteration in the functional markers of liver, kidney, brain and testis. These parameters were reinstated near to the control values following administration of AlCl3 (100 mg/kg body wt./day) along with fruit extract of Tt (100 mg/kg body wt./day) for the same duration. The results suggested that chelating property of Tt against aluminium accumulation might have resulted in the reinstatement of the lipid peroxidation, activities of antioxidant enzymes and the levels of the functional markers in the liver, kidney, brain, and testis.
Page(s): 179-186
URI: http://nopr.niscair.res.in/handle/123456789/42645
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.53(5&6) [October-December 2016]

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