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Title: Two novel polychiral furanopyrans from Orthosiphon diffusus (Benth.)
Authors: Majhi, Anjoy
Holla, Harish
Shinde, Dhananjay
Srinivasulu, Gannoju
Krishna, Arepalli Sai
Rao, Janapala Venkateswara
Das, Biswanath
Keywords: Orthosiphon diffusus;Polychiral furanopyrans;AM-1;AM-2;Natural products;Structure elucidation;Cytotoxicity
Issue Date: Aug-2017
Publisher: NISCAIR-CSIR, India
Abstract: Chemical investigation on Orthosiphon diffusus has resulted in the isolation of two new polychiral furanopyrans, orthodiffenes AM-1 and AM-2 which have been thoroughly characterized by detailed spectroscopic studies including IR, NMR (1D and 2D) and FABMS spectra. The in vitro cytotoxic activity of these two compounds has been tested against U-937 and HeLa cells using camptothecin and etoposide as the positive controls. Both the metabolites show modest activity against HeLa cells with IC50 values of 26.98 µg/mL and 21.18 µg/mL, respectively.
Page(s): 855-861
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(08) [August 2017]

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