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Title: Facile, eco-friendly and one-pot synthesis of 3,4-disubstituted isoxazol- 5(4H)-ones using starch solution as a reaction media
Authors: Vekariya, Rajesh H
Patel, Hitesh D
Keywords: Isoxazol-5(4H)-one;Starch solution;One-pot;Multi-component;Microwave irradiation (MWI)
Issue Date: Aug-2017
Publisher: NISCAIR-CSIR, India
Abstract: A one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes has been developed using starch solution as a reaction media. Starch solution has been employed as an environmentally benign and commercially available catalytic system for this synthesis. This cyclo-condensation reaction has been performed in aqueous ethanol as an environmentally benign solvent at 90°C as well as under microwave irradiation (MWI, 300 W) giving 3,4-disubstituted isoxazol-5(4H)-one derivatives in excellent yields. The use of a nontoxic, reusable and biodegradable catalytic system is one of the superior advantages of this protocol. The superior features of the present methodology are mild reaction conditions, excellent yields, high atom-economy, easy work-up process, short reaction times and use of microwave irradiation conditions.
Page(s): 890-896
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.56B(08) [August 2017]

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