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|Title:||Evaluation of antiangiogenic activity through tubulin interaction of chloroform fraction of the feather star, <i style="">Lamprometra palmata palmata</i>|
|Abstract:||<smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place" downloadurl="http://www.5iantlavalamp.com/"> Tubulin binding agents have received considerable interest as potential tumour-selective angiogenesis-targeting drugs. The present study elucidates that chloroform fraction (CC) isolated from methanol extract of the feather star <i style="">Lamprometra palmata palmata </i>has a tubulin binding property. With the quantification of chick chorioallantoic (CAM) assay, we further demonstrate that CC significantly and dose-dependently inhibits proliferation, migration of endothelial cells and exhibits antiangiogenic effect with ID<sub>50 </sub>10ng/10ml. It showed moderate cytotoxicity with IC<sub>50</sub> 192 mg/ml. In addition, CC arrested onion root tip cells at prometaphase phase. We demonstrate that these effects of CC are attributable to its property to inhibit polymerization of tubulin. These findings show that CC is a candidate antiangiogenic agent and needs further purification for the specific compound, which is responsible for all these activities. </smarttagtype>|
|Appears in Collections:||IJMS Vol.38(1) [March 2009]|
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