Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/42358
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dc.contributor.authorSathishkumar, S-
dc.contributor.authorKavitha, Helen P-
dc.date.accessioned2017-07-10T06:22:34Z-
dc.date.available2017-07-10T06:22:34Z-
dc.date.issued2017-07-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/42358-
dc.description732-739en_US
dc.description.abstractIn this paper, has been described the synthesis of some novel tetrazolodiazepine derivatives starting from piperidin-4-ones, with a view to test the novel compounds for various biological activities. The structures of the synthesized compounds have been established by IR, 1H and 13C NMR, mass and elemental analysis. Representative compounds have been characterized by COSY, HETCOR and DEPT 135 spectra. The representative compounds of the tetrazolodiazepine have been tested for anti-inflammatory activity by carrageenan induced paw edema method. From the results of the in vivo study, it is observed that the compounds taken for the study possess fairly good activity. Among the synthesized compounds, 6,8-bis-(3-chlorophenyl)-5-methyl-6,7,8,9-tetrahydro-5H-tetrazolo[1,5-d][1,4]diazepine 3c shows potent anti-inflammatory activity.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.56B(07) [July 2017]en_US
dc.subjectSynthesisen_US
dc.subjectCharacterizationen_US
dc.subjectTwo dimensional NMR studiesen_US
dc.subjectTetrazolodiazepineen_US
dc.subjectAnti-inflammatory activityen_US
dc.titleSynthesis, characterization and anti-inflammatory evaluation of novel substituted tetrazolodiazepine derivativesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.56B(07) [July 2017]

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