NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(05) [May 2009] >

Title: Luteolin ameliorates ferric nitrilotriacetic acid induced renal toxicity and tumor promotional response in rat
Authors: Sultana, Sarwat
Prasad, Lakshmi
Jahangir, Tamanna
Keywords: Cell proliferation response
Ferric nitrilotriacetate
Issue Date: May-2009
Publisher: CSIR
Abstract: Ferric nitrilotriacetic acid (Fe-NTA) (9 mg Fe/kg body weight, ip) caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in renal lipidperoxidation, serum toxicity markers viz. creatinine, blood urea nitrogen, hydrogen peroxide generation, ornithine decarboxylase activity and [3H] thymidine incorporation into renal DNA in wistar rats. However, pretreatment of animals with luteolin (10 and 20 ┬Ámol/kg body weight) for 7 consecutive days resulted in significant decrease in above parameters level. Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant level. The enhanced reduced glutathione level and enzyme activities involved in xenobiotic metabolism and maintaining antioxidant status of cells is suggestive of a chemopreventive efficacy of luteolin against Fe-NTA mediated oxidative stress, toxicity and cell proliferation response in rats.
Page(s): 355-360
ISSN: 0019-5189
Source:IJEB Vol.47(05) [May 2009]

Files in This Item:

File Description SizeFormat
IJEB 47(5) 355-360.pdf158.83 kBAdobe PDFView/Open
 Current Page Visits: 839 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 132499 since 01-Sep-2015  Last updated on 20-May-2016Webmaster: