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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(05) [May 2009] >
| Title: | Protective effects of Petroselinum crispum (Mill) Nyman ex A. W. Hill leaf extract on D-galactose-induced oxidative stress in mouse brain |
| Authors: | Vora, Shreya R
Patil, Rahul B
Pillai, Meena M |
| Keywords: | Catalase
D-galactose
Glutathione peroxidase
Lipid peroxidation
Petroselinum crispum
Superoxide dismutase |
| Issue Date: | May-2009 |
| Publisher: | CSIR |
| Abstract: | With an aim to examine the effect of ethanolic extract of P. crispum (Parsley) leaves on the D-galactose-induced oxidative stress in the brain of mouse, the activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) involved in oxygen radical (OR)-detoxification and antiperoxidative defense were measured in conjunction with an index of lipid peroxidation in mitochondrial fraction of various regions of the mouse brain. A significant decrease in superoxide dismutase and glutathione peroxidase activity was observed in D-galactose-stressed mice, while catalase activity was increased. Treatment of D-galactose-stressed mice with the ethanolic extract of P. crispum showed protection against the induced oxidative stress in brain regions. Concentration of thiobarbituric acid-reactive product was greatly elevated in D-galactose stress-induced mice and was significantly reduced in the brain regions of these mice upon treatment with P. crispum. It is postulated that parsley shows a protective effect against mitochondrial oxidative damage in the mouse brain. |
| Page(s): | 338-342 |
| ISSN: | 0019-5189 |
| Source: | IJEB Vol.47(05) [May 2009]
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