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Title: Protective effects of Petroselinum crispum (Mill) Nyman ex A. W. Hill leaf extract on D-galactose-induced oxidative stress in mouse brain
Authors: Vora, Shreya R
Patil, Rahul B
Pillai, Meena M
Keywords: Catalase
Glutathione peroxidase
Lipid peroxidation
Petroselinum crispum
Superoxide dismutase
Issue Date: May-2009
Publisher: CSIR
Abstract: With an aim to examine the effect of ethanolic extract of P. crispum (Parsley) leaves on the D-galactose-induced oxidative stress in the brain of mouse, the activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) involved in oxygen radical (OR)-detoxification and antiperoxidative defense were measured in conjunction with an index of lipid peroxidation in mitochondrial fraction of various regions of the mouse brain. A significant decrease in superoxide dismutase and glutathione peroxidase activity was observed in D-galactose-stressed mice, while catalase activity was increased. Treatment of D-galactose-stressed mice with the ethanolic extract of P. crispum showed protection against the induced oxidative stress in brain regions. Concentration of thiobarbituric acid-reactive product was greatly elevated in D-galactose stress-induced mice and was significantly reduced in the brain regions of these mice upon treatment with P. crispum. It is postulated that parsley shows a protective effect against mitochondrial oxidative damage in the mouse brain.
Page(s): 338-342
ISSN: 0019-5189
Source:IJEB Vol.47(05) [May 2009]

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