Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/4178
Title: Synthesis and antiulcer activity study of 1,4-dihydropyridines and their Mannich bases with sulfanilamide
Authors: Subudhi, B B
Panda, P K
Bhatta, D
Keywords: Ethyl acetoacetate
1,4-dihydropyridines
sulfanilamide
antiulcer activity
Issue Date: May-2009
Publisher: CSIR
Abstract: 3,5-Diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substi­tu­t­ed)-pyridines <b style="">1a-e</b> are prepared following Hantzsch pyridine synthesis<sup> </sup>by condensation of ethyl acetoacetate with different aromatic aldehydes in presence of ammonium hydroxide. Compounds <b style="">1a-e</b> on reaction with paraformaldehyde and sulfanilamide yielded 3,5-diethoxycarbonyl-1-[(4'-sulfamoyl-1'-amino methyl) phenyl]-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines <b style="">2a-e</b>. The antiulcer activities have been performed by estimating volume of gastric acid, <i style="">p</i>H, free acidity, total acidity and ulcer index. The antiulcer activity of 1,4-dihydropyridines is enhanced significantly on conjunction with sulfanilamide. Substitution of methoxy group increased the antiulcer potential of the compounds.
Description: 725-728
URI: http://hdl.handle.net/123456789/4178
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(05) [May 2009]

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