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IJC-B Vol.48B(05) [May 2009] >


Title: Synthesis and antiulcer activity study of 1,4-dihydropyridines and their Mannich bases with sulfanilamide
Authors: Subudhi, B B
Panda, P K
Bhatta, D
Keywords: Ethyl acetoacetate
1,4-dihydropyridines
sulfanilamide
antiulcer activity
Issue Date: May-2009
Publisher: CSIR
Abstract: 3,5-Diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substi­tu­t­ed)-pyridines 1a-e are prepared following Hantzsch pyridine synthesis by condensation of ethyl acetoacetate with different aromatic aldehydes in presence of ammonium hydroxide. Compounds 1a-e on reaction with paraformaldehyde and sulfanilamide yielded 3,5-diethoxycarbonyl-1-[(4'-sulfamoyl-1'-amino methyl) phenyl]-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines 2a-e. The antiulcer activities have been performed by estimating volume of gastric acid, pH, free acidity, total acidity and ulcer index. The antiulcer activity of 1,4-dihydropyridines is enhanced significantly on conjunction with sulfanilamide. Substitution of methoxy group increased the antiulcer potential of the compounds.
Page(s): 725-728
ISSN: 0376-4699
Source:IJC-B Vol.48B(05) [May 2009]

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