Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/4175
Title: Synthesis and antimicrobial evaluation of some alkoxyphthalimide derivatives of naphthyridine
Authors: Bhambi, Dinesh
Salvi, Vijay Kumar
Bapna, Archita
Pemawat, Gangotri
Talesara, G L
Keywords: Naphthyridine
ω-bromoalkoxyphthalimide
multicomponent condensation
antimicrobial activity
<i style="">N</i>-hydroxy­phthalimide
Issue Date: May-2009
Publisher: CSIR
Abstract: 5-(4-Substitutedphenyl)-8,8-dimethyl-5,8,9,10-tetrahydrobenzo[<i style="">b</i>][1,8]naphthyridin-7<i style="">H</i>-one <b style="">1a-e</b> have been converted to their <i style="">N</i>-substituted alkoxyphthalimide derivatives using two alternative pathways. In route one, <b style="">1a-e </b>are treated with formalin (37%) to yield 5-(4-substitutedphenyl)-10-(hydroxymethyl)-8,8-dimethyl-5,8,9,10-tetrahydro­benzo­[<i style="">b</i>][1,8]­naph­thyridin-6-7<i style="">H</i>-one <b style="">2a-e</b>, which is further changed to corresponding chloro derivatives <b style="">3a-e </b>by the treatment with thionyl chloride. Condensation of <b style="">3a-e </b>with <i style="">N</i>-hydroxyphthalimide furnished the final compounds 2-{[5-(4-substitutedphenyl)-8,8-dimethyl-6-oxo-6,7,8,9-tetrahydrobenzo[<i style="">b</i>][1,8]naphthyridin-10-5<i style="">H</i>-yl]methoxy}phthalimide <b style="">4a-e</b>. In another route, <b style="">1a-e</b> is directly condensed with ω-bromoalkoxyphthalimide to yield higher homologues of <b style="">4a-e</b> <i style="">i. e.</i> 2-{2-[5-(4-substituted phenyl)-8,8-dimethyl-6-oxo-6,7,8,9-tetrahydrobenzo[<i style="">b</i>][1,8]naphthyridin-10-5<i style="">H</i>-yl]ethoxy} phthalimide derivatives <b style="">5a-e</b>.<b style=""> </b>Structures of all the synthesized compounds have been established on the basis of elemental analysis and spectral studies. All the synthesized compounds have been screened for antibacterial and antifungal activities.
Description: 697-704
URI: http://hdl.handle.net/123456789/4175
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(05) [May 2009]

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