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dc.contributor.authorVenepally, Vijayendar-
dc.contributor.authorPrasad, R B N-
dc.contributor.authorPoornachandra, Y-
dc.contributor.authorKumar, C Ganesh-
dc.contributor.authorJala, Ram Chandra Reddy-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractThe aim of this study is to synthesize and examine the in vitro anticancer, antioxidant and antimicrobial activities of N-fatty acyl derivatives of 4,5-dimethoxy tryptamine. A series of new N-fatty acyl derivatives of 4,5-dimethoxy tryptamine compounds derived from 2,3-dimethoxy benzaldehyde have been prepared. The synthesized compounds have been characterized and screened for anticancer, antioxidant and antimicrobial activities. The synthesized derivatives have been evaluated for their cytotoxicity on various cell lines. Compounds 9a and 9g have shown promising cytotoxicity, while compounds 9c, 9d and 9e have shown moderate activity for all the tested cancer cell lines. The antioxidant activities have been determined with regard to DPPH radical scavenging activity, superoxide free radical scavenging activity and inhibition of lipid peroxidation. Based on the results, it has been observed that N-fatty acyl derivatives of 4,5-dimethoxy tryptamine exhibit promising antioxidant activity. In particular, the undecenoic acid-based derivative 9d shows good antioxidant activity in all the three assays. Further, the compound 9d exhibits significant antimicrobial activity against Bacillus subtilis MTCC 121 with MIC value of 15.6 µg/mL.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.56B(05) [May 2017]en_US
dc.subjectDPPH radical scavengingen_US
dc.subjectSuper oxide free radical scavengingen_US
dc.subjectLipid peroxidationen_US
dc.titleSynthesis and biological evaluation of some new N-fatty acyl derivatives of 4,5-dimethoxy tryptamineen_US
Appears in Collections:IJC-B Vol.56B(05) [May 2017]

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